Preheat oven to 350 degrees.
Lightly grease a cookie sheet or line with parchment paper, set aside.
Add butter, peanut butter, granulated sugar and brown sugar in a large bowl and cream using a hand mixer or a stand mixer fitted with the paddle attachment.
Add egg, mix until combined.
In a separate bowl, whisk together dry ingredients (flour, baking soda, baking powder, salt).
Add dry ingredients to wet ingredients, about ½ cup at a time. Mix until combined.
Remove the ganache dollops from the freezer.
Use a cookie dough scoop a spoon to scoop out a 1-inch dough ball. Then flatten the dough out and place a frozen ganache dollop in the center of the dough. Fold the dough over the ganache (ensure it is fully covered by cookie dough) and roll dough into a ball.
Place the dough balls on to baking sheet, leaving at least 1 inch in between each cookie.
Bake for 8-10 minutes or until the edges of the cookies just begin to crack.
Let cookies cool on baking sheet for 10-15 minutes, then transfer to cooling rack.